Below follows a selection of references and original publications. Further and more recent research results are submitted for publication but have not yet reached acceptance status.

 

Key References

Batenburg WW, Garrelds IM, Bernasconi CC, Juillerat-Jeanneret L, van Kats JP, Saxena PR, Danser AH.  Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries.  Circulation.2004 May 18;109(19):2296-3

Benndorf, Böger, Ergun, Steenpass. Wieland:Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation in human endothelial cells. Circ Res 93:2003

Carey RM, Jin XH, Siragy HM.Role of the angiotensin AT₂receptor in blood pressure regulation and therapeutic implications. Am J Hypertens. 14(6):98S-102S,2001.

Davy KP, Hall JE. Obesity and hypertension:two epidemics or one?  Am J Physiol Regul Integr Comp Physiol2004 May;286(5):R803-13.

De Paepe B, Verstraeten VLRM, De Potter CR, Bullock GR. Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression. Histochem Cell Biol. 117:13-19,2002.

Fournier A, Messerli FH, Achard JM, Fernandez L.Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials.  J Am Coll Cardiol.2004 Apr 21;43(8):1343-7

Gallinat S, Busche S, Raizada MK, Sumners C. The angiotensin II type 2 receptor: an enigma with multiple variations. Am J Physiol Endocrinol Metab. 278(3):E357-74,2000.

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger TH. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 52(3):415-72,2000.

Iwai M, Liu HW, Chen R, Ide A, Okamoto S, Hata R, Sakanaka M, Shiuchi T, Horiuchi M. Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation.2004 Aug 17;110(7):843-8.

Johansson B, Holm M, Ewert S, Casselbrant A, Pettersson A, Fandriks L.
Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat. Am J Physiol; Gastrointest Liver Physiol 280(6):G1254-60,2001.

Kaschua E, Unger T.Angiotensin AT1/AT₂Receptors: Regulation, Signalling and Function. Blood Pressure;12:70-882003

Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol. 89(Suppl):3A-9A,2002.

Wan Y, Wallinder C, Johansson B, Holm M, Mahalingam AK, Wu X, Botros M, Karlen A, Pettersson A, Nyberg F, Fandriks L, Hallberg A, Alterman M.First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT₂receptor agonist in vivo.  J Med Chem.2004 Mar 11;47(6):1536-46.

Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingham A K, Xiongyu W, Johansson B, Holm M, Botros M, Karlén A, Pettersson A, Nyberg F, Fändriks L, Gallo-Payet N, Hallberg A, Alterman M. Design, Synthesis and Biological Evaluation of the First Selective Nonpeptide AT₂Receptor Agonist. J Med Chem in press

Widdop RE, Jones ES, Hnnan RE, Gaspari TA.  Angiotensin AT₂receptors: cardiovascular hope or hype? Br J Pharmacol.2003 Nov;140(5):809-24.

Volpe, Musumeci, De Paolis, Savona, Morganti: Angiotensin II AT₂receptor subtype:
An uprising frontier in cardiovascular disease? Journal of Hypertension 21:1429-14432003