The article "Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor B" by Rompe, Dr. Steckelings, Dr. Unger and co-workers is available online at Hypertension from the 15th of February 2010.
This article verifies that Compound 21 has an ability to lower inflammation at the same level as hydrocortisone, which is the the reference drug in long standing inflammatory conditions,for example in dermatologic diseases and inflammation in the respiratory tracts. The results further confirms the good pharmacological qualities of Compound 21, and strengthens the therapeutic platform for Angiotensin type 2 Agonism.
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